Tyrant virus IV

The believed abandoned Training facility too, fell. Two umbrella teams sent to evaluate it for re-activation were killed by the creatures from within and outside of the facility.
From there, stories started stemming from the forest; several killings took place and an elite team of paramilitary units, the S.T.A.R.S. Bravo team, was sent from Raccoon City to destroy the threat, oblivious to its real cause. Only four of these members, Rebecca Chambers, Enrico Marini, Kenneth J. Sullivan, and Richard Aiken survived the night. All of them ended up holed up in the massive Spencer estate and its adjacent areas, where the next day, the S.T.A.R.S. Alpha team entered as well, after suffering a similar fate at the hands of the pack of Cerberi.
Later on, the remaining members of S.T.A.R.S. met up at the underground laboratory where the Tyrant T-002 was kept. This Tyrant killed, albeit temporarily, Albert Wesker, and was killed by a rocket blast in the second brawl it offered the remaining S.T.A.R.S..
After the demolition of the manor, the virus sources were thought stopped definitively, but when William Birkin's subterranean laboratories were attacked by Umbrella's Black Ops in September 1998 in an effort to retrieve his G-virus, another outbreak ensued. This infection encompassed all of Raccoon and ended in the forced termination of the entire city. Umbrella was immediately exposed as creator of the virus due to the enormous amount of evidence produced from the scarce survivors, and was shut down.

Still, another outbreak was induced in late 1998, on Rock Fort Island, this time by the revived Albert Wesker and his new employers, referred to only as the Organization. This ended in the partial demolition of the Umbrella installations there and the total destruction of the South Pole Umbrella Research Center.
Yet another occurred in 1998, this time on Sheena Island; an Umbrella owned "Tyrant Plant". Hundreds of adolescents from across the globe were kidnapped and taken there to be dissected, to retrieve a hormone important for Tyrant development.^[10] This infection was caused by the - now mad with power - commander Vincent Goldman. The island was "sterilized" when facility's self-destruct system was activated.