American agents Leon S. kennedy and Jack Krauser are sent to south america to capture the Drug lord and leader of the Sacred Snakes, Javier Hidalgo only to find out that the entire village has been infected with the t-virus and partly the t-veronica virus. Manuela Hidalgo escapes from Javier's mansion, she's found by the 2 agents in a church outside the village, she agrees into helping them find Javier. The 3 later find him and he becomes infused with the Veronica virus and is killed.
Jack Krauser is believed to have perished in a helicopter crash, but under debated circumstances of how he survived, eventually begins working for Albert Wesker.
